The class is set by the most complex feature; enhancement is the key discriminator.
Well-defined, thin (≤2 mm) smooth wall; homogeneous simple fluid (−9 to 20 HU on CT / CSF-like on MRI); no septa or calcification. Wall may enhance.
Thin (≤2 mm) smooth wall with: 1–3 thin enhancing septa (any calcification); or homogeneous hyperattenuating ≥70 HU (noncontrast CT); or homogeneous nonenhancing >20 HU (renal mass protocol CT); or homogeneous −9 to 20 HU (noncontrast CT); or homogeneous 21–30 HU (portal venous phase); or homogeneous low-attenuation too small to characterize. MRI: 1–3 enhancing septa; or markedly T2-hyperintense (≈CSF); or markedly T1-hyperintense (≈2.5× parenchyma).
Smooth minimally thickened (3 mm) enhancing wall, or 3 mm thickening of ≥1 enhancing septum, or many (≥4) smooth thin (≤2 mm) enhancing septa. MRI also: heterogeneously hyperintense on unenhanced fat-saturated T1.
One or more enhancing thick (≥4 mm) or enhancing irregular (≤3 mm obtusely-margined convex protrusion[s]) walls or septa. ~50% malignant.
One or more enhancing nodule(s): ≥4 mm convex protrusion with obtuse margins, or a convex protrusion of any size with acute margins.
I / II → benign, no follow-up. IIF → surveillance (CT or MRI without and with IV contrast at 6 and 12 months, then yearly for 5 years; morphologic change → refer). III / IV → refer for management. (Management per ACR Incidental Renal Mass white paper, Fig 3.)
Silverman SG, et al. Bosniak Classification of Cystic Renal Masses, Version 2019. Radiology 2019;292:475–488.