High-risk features include older age, heavy smoking, other known risk factors, irregular or spiculated margins, and upper-lobe location. Low risk applies to minimal or absent smoking history and other risk factors. Clinical judgment and, where appropriate, a validated risk calculator should guide the low- vs high-risk choice.
Measure nodules as the average of long- and short-axis diameters on the same image, rounded to the nearest mm. Volumetric thresholds in the source: <100 mm³ (<6 mm), 100–250 mm³ (6–8 mm), >250 mm³ (>8 mm). For part-solid nodules, the solid-component size drives suspicion: a persistent solid component ≥6 mm is highly suspicious.
MacMahon H, Naidich DP, Goo JM, et al. Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017. Radiology 2017;284:228–243. Tables: Solid (A) and Subsolid (B) nodules.